My name is Matteo Aletti and I am from Italy where I studied Mathematical Engineering at Politecnico di Milano.
Mathematical Engineer is a relatively young course which combines theoretical mathematics with computer science to solve engineering problems.
I joined REVAMMAD project in January 2014 from Paris at the INRIA (Institut national de recherche en informatique et en automatique) under the supervision of Jean-Frédéric Gerbeau and Damiano Lombardi in the REO team.
Within the project I’m working on the mathematical modeling of the micro-circulation.
In the human retina it is possible to take many different measurements mostly based on imaging techniques, but still there are some hidden quantities that are difficult to be measured, for example pressure and/or blood flow can be very difficult to measure.
Thanks to mathematical modelling it is possible to perform computer simulations to enrich the available data and to get access to such unavailable quantities.
In particular, in a very first phase of my PhD I reconstructed a three dimensional representation of the retinal network starting from two dimensional segmented images. With such a realistic geometry it is now possible to run haemodynamics simulations and to estimate fluid dynamics parameters, like flow rates for instance.
Currently I am designing a model to describe the interactions between the blood flow and the arteriolar vessels in such a way that it is possible to take into account more complex phenomena like auto-regulation which is an active response of the arteriolar wall to a sudden increase in the systemic pressure.